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Calcineurin inhibitor toxicity in kidney transplants
Influence of the therapeutic procedure on the long-term function of the transplant
The use of calcineurin inhibitors as immunosuppressants led to a significant reduction in acute rejection reactions, particularly in the first year after transplantation.
However, this positive effect may be lost in the long term due to toxic effects on the transplant. Vascular changes (hyaline vasculopathy) and fibrotic remodeling (striped fibrosis) lead to a deterioration in graft function up to graft failure.
Various treatment options are available, such as reducing the calcineurin inhibitor dose or replacing it with other immunosuppressants (proliferation inhibitors, mTOR inhibitors).
The aim of the study is to investigate the function of the transplant, including cardiovascular parameters, after biopsy-proven calcineurin inhibitor toxicity, depending on the chosen therapeutic procedure. In addition, possible side effects under therapy with proliferation inhibitors or mTOR inhibitors will be investigated.
Project management
Prof. Dr. med. Claudia Sommerer
claudia.sommerer@med.uni-heidelberg.de
+49 6221 9112 0
Persons involved
Cand. med. dent. Laura Baumgarten